Publications

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Claudia D Lovell, Nikhil Jiwrajka, Hayley K Amerman, Michael P. Cancro, Montserrat Anguera. Xist Deletion in B Cells Results in Systemic Lupus Erythematosus Phenotypes. Biorxiv 2024. [DOI]

Forsyth KS, Toothacre NE, Jiwarjka N, Driscoll AM, Shallberg LA, Cunningham-Rundles C, Bartmettler S, Farmer J, Verbsky J, Routes J, Beiting DP, Romberg N, May M, Anguera MC. NFkB signaling links dynamic X Chromosome Inactivation maintenance and T cell activation. Biorxiv 2024. [PMID: 38405871]

Forsyth KS, Jiwarjka N, Lovell CD, Toothacre N, Anguera MC. The ConneXion Between Sex and Immune Responses. Nature Reviews Immunology (accepted) [PMID: 38383754]

Jiwrajka N, Toothacre NE, Beethem ZT, Sting S, Forsyth KS, Dubin AH, Driscoll A, Stohl W, Anguera MC. (2023) “Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models.”  J. Autoimmun. Sept; 139:103084. [PMID: 37399593]

Sierra I, Pyfrom S, Weiner A, Zhao G, Driscoll A, Yu X, Gregory BD, Vaughan AE, Anguera MC. (2022) “Unusual X chromosome inactivation maintenance in female alveolar type 2 cells is correlated with increased numbers of X-linked escape genes and sex-biased gene expression”. Stem Cell Reports. Dec 27:S2213-6711(22)00594-X.  [PMID: 36638790]

Lovell, C. D. and Anguera, M.C. (2022) “Long noncoding RNAs that function in nutrition:  Lnc-ing nutritional cues to metabolic pathways.” Annu Rev Nutr. 2022 Apr 18. [PMID: 35436418]

Jiwrajka, N. and Anguera M.C. (2022) “The X in seX-biased immunity and autoimmune rheumatic disease”. J Exp Med. Jun 6; 291(6):e20211487. [PMID:35510951]

Volkmann ER, Siegfried J, Lahm T, Ventetulo C, Mathai SC, Stenn V, Herzog E, Shansky R, Anguera MC, Danoff S, Giles JT, Lee YC, Drake W, Maier LA, Lachowicz-Scroggins M, Park H, Banerjee K, Fessel J, Reineck L, Vuga L, Crouser E, Feghali-Bostwick C. (2022) “NHLBI Report: Impact of Sex and Gender on autoimmune lung disease, opportunities for future research”. Am J Respir Crit Care Med. May 13. [PMID: 35549658]

Pyfrom S, Paneru B, Knoxx, J, Posso S, Buckner J, Cancro M, Anguera MC. (2021) “The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients”. Proc Natl Acad Sci. Jun 15;118 (24). [PMID: 34103397]

Forsyth, Katherine S. and Anguera, M.C. (2021) “Time to get ill: the intersection of viral infections, sex, and the X chromosome.”  Curr Opin Physiol. Feb; 19:62-72. [PMCID: PMC7553007]

Chang S, Hur SK, Naveh NSS, Thorvaldsen JL, French DL, Gagne AL, Jobaliya CD, Anguera MC, Bartolomei MS, Kalish JM. (2021) “Derivation and investigation of the first human cell-based model of Beckwith-Wiedemann syndrome”. Epigenetics. Dec 16(12):1295-1305. [PMID: 33300436]

Syrett CM, Sierra I, Beethem ZT, Dubin AH, and Anguera M.C. (2019) “Loss of epigenetic modifications on the inactive X chromosome and sex-biased gene expression profiles in B cells from NZB/W F1 mice with lupus-like disease.” J Autoimmun. Nov 25:102357. [PMID: 31780316]

Syrett Camille M, Anguera Montserrat C: When the balance is broken: X-linked gene dosage from two X chromosomes and female-biased autoimmunity. [PMID 31125996] Journal of leukocyte biology May 2019.

Kotzin Jonathan J, Iseka Fany, Wright Jasmine, Basavappa Megha G, Clark Megan L, Ali Mohammed-Alkhatim, Abdel-Hakeem Mohamed S, Robertson Tanner F, Mowel Walter K, Joannas Leonel, Neal Vanessa D, Spencer Sean P, Syrett Camille M, Anguera Montserrat C, Williams Adam, Wherry E John, Henao-Mejia Jorge: The long noncoding RNA regulates CD8 T cells in response to viral infection.[PMID 31138702] Proceedings of the National Academy of Sciences of the United States of America 116(24): 11916-11925, Jun 2019.

Syrett Camille M, Paneru Bam, Sandoval-Heglund Donavon, Wang Jianle, Banerjee Sarmistha, Sindhava Vishal, Behrens Edward M, Atchison Michael, Anguera Montserrat C: Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases. [PMID 30944248 JCI insight 4(7), Apr 2019.

Syrett Camille M, Sindhava Vishal, Sierra Isabel, Dubin Aimee H, Atchison Michael, Anguera Montserrat C: Diversity of Epigenetic Features of the Inactive X-Chromosome in NK Cells, Dendritic Cells, and Macrophages. [PMID 30671059] Frontiers in immunology 9: 3087, 2018.

Le Coz Carole, Trofa Melissa, Syrett Camille M, Martin Anna, Jyonouchi Harumi, Jyonouchi Soma, Anguera Montserrat C, Romberg Neil: CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation.[PMID 29499223] The Journal of allergy and clinical immunology 141(6): 2308-2311.e7, Jun 2018.

Syrett Camille M, Sierra Isabel, Berry Corbett L, Beiting Daniel, Anguera Montserrat C: Sex-Specific Gene Expression Differences Are Evident in Human Embryonic Stem Cells and During In Vitro Differentiation of Human Placental Progenitor Cells. [PMID 29993333] Stem cells and development 27(19): 1360-1375, Oct 2018.

Wang Jianle, Anguera Montserrat C: In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells. [PMID 28362386] Journal of visualized experiments : JoVE(121), Mar 2017.

Syrett Camille M, Sindhava Vishal, Hodawadekar Suchita, Myles Arpita, Liang Guanxiang, Zhang Yue, Nandi Satabdi, Cancro Michael, Atchison Michael, Anguera Montserrat C: Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells. [PMID 28991910] PLoS genetics 13(10): e1007050, Oct 2017.

Penkala Ian, Wang Jianle, Syrett Camille M, Goetzl Laura, López Carolina B, Anguera Montserrat C: lncRHOXF1, a Long Noncoding RNA from the X Chromosome That Suppresses Viral Response Genes during Development of the Early Human Placenta. [PMID 27066803] Molecular and cellular biology 36(12): 1764-75, Jun 2016.

Wang Jianle, Syrett Camille M, Kramer Marianne C, Basu Arindam, Atchison Michael L, Anguera Montserrat C: Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X. [PMID 27001848] Proceedings of the National Academy of Sciences of the United States of America 113(14): E2029-38, Apr 2016.

Luo Mengcheng, Zhou Jian, Leu N Adrian, Abreu Carla M, Wang Jianle, Anguera Montserrat C, de Rooij Dirk G, Jasin Maria, Wang P Jeremy: Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis. [PMID 25634095] PLoS genetics 11(1): e1004954, Jan 2015.

Lessing D, Anguera MC, Lee JT.: X chromosome inactivation and epigenetic responses to cellular reprogramming. [PMID 23662665] Annu Rev Genomics Hum Genet. 14: 85-110, May 2013.

Anguera Montserrat C, Sadreyev Ruslan, Zhang Zhaoqing, Szanto Attila, Payer Bernhard, Sheridan Steven D, Kwok Showming, Haggarty Stephen J, Sur Mriganka, Alvarez Jason, Gimelbrant Alexander, Mitalipova Maisam, Kirby James E, Lee Jeannie T: Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. [PMID 22770242] Cell stem cell 11(1): 75-90, Jul 2012.

Anguera Montserrat C, Ma Weiyuan, Clift Danielle, Namekawa Satoshi, Kelleher Raymond J, Lee Jeannie T: Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. [PMID 21912526] PLoS genetics 7(9): e1002248, Sep 2011.

Kim Daniel H, Jeon Yesu, Anguera Montserrat C, Lee Jeannie T: X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes. [PMID 21376830] Seminars in cell & developmental biology 22(4): 336-42, Jun 2011.

Field Martha S, Anguera Montserrat C, Page Rodney, Stover Patrick J: 5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887. [PMID 19022216] Archives of biochemistry and biophysics 481(2): 145-50, Jan 2009.

Anguera Montserrat C, Liu Matthew, Avruch Joseph, Lee Jeannie T: Characterization of two Mst1-deficient mouse models. [PMID 18942145] Developmental dynamics : an official publication of the American Association of Anatomists 237(11): 3424-34, Nov 2008.